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How CBD and THC Work Together: The Entourage Effect

While cannabis is made up of over 100 cannabinoids, two cannabinoids are particularly prominent- CBD and THC. THC is the main psychoactive component in cannabis. In other words, this is the chemical that delivers the mentally stimulating, euphoric effects. Meanwhile, CBD is non-psychoactive but is said to have a range of benefits for your body and mind.

When you smoke cannabis or use it in other ways, CBD and THC work together to enhance the effects you experience. You also benefit from a range of other cannabinoids such as CBN and CBG as well as a range of terpenes. The effect of these components working together is known as the entourage effect. Here’s a guide on what CBD and THC do and how they work together to create the entourage effect.

What Does CBD Do?

CBD is one of the most prominent non-psychoactive cannabinoids found in cannabis. CBD is non-psychoactive, meaning it won’t get you high or give you any psychoactive effects like THC. However, CBD is well known for its ability to provide a range of medical benefits, especially when working in unison with THC.

While THC is cerebrally stimulating, CBD is calming and relaxing. Studies suggest that CBD helps relieve pain and inflammation, whether it’s a case of nagging chronic pain or muscle strains and aches. CBD is also said to help with anxiety and sleep disorders due to its mentally calming properties. Other studies suggest CBD can help with epileptic seizuresdepressionskin problems, and more.

Generally, strains of cannabis contain high levels of THC and much lower levels of CBD. However, there are some strains with particularly high levels of CBD. These are often preferred by users who are less interested in getting high and more interested in getting the relaxing and relieving effects of cannabis. You can also use a range of CBD-infused products, such as CBD OilsCBD Capsules, and CBD Edibles.

What Does CBD Do

What Does THC Do?

THC is the sole psychoactive component in cannabis, meaning it’s responsible for getting you high. When you smoke weed and feel a powerful mental rush and physical body tingles, this is mainly due to the effects of THC. It helps activate reward circuits in the brain as well as activating the body’s endocannabinoid system which can have all kinds of effects on pain sensation, mood, memory, and more.

When you use THC, you’ll likely experience euphoria, heightened senses, and a boost in creativity. Every activity seems more fun, whether you’re talking with friends or relaxing at home and watching TV shows or listening to music. The physical effects are also relaxing and can often be sedating, making it much easier to fall asleep.

Most users simply smoke or vape cannabis to get the effects of THC. Most strains contain around 15-25% THC, with some containing more or less. However, you can also get the effects of THC by using THC-infused products including EdiblesTincturesCapsules, and Vapes. All of these methods of consumption make for convenient ways to get high.

How CBD and THC Work Together: The Entourage Effect

While both CBD and THC can have all kinds of effects on your body when taken alone, they work best in conjunction with one another. CBD and THC work together on your body to provide a range of enjoyable physical and mental effects. This ability to work well in unison is what’s known as the entourage effect.

THC and CBD can work well together in various ways. For instance, while the effects of THC can be mentally overwhelming in some cases, CBD seems to tame these effects to provide a more enjoyable mental high without negative side effects. A study on using cannabis for stress, anxiety, and depression found that high-CBD strains were especially helpful for reducing stress and depression.

These cannabinoids also have an entourage effect on your body. While both THC and CBD are said to help with relieving pain, inflammation, headaches, migraines, and other such issues, they work especially well when used together. As such, many users even use products containing both THC and CBD to take advantage of the entourage effect.

Other Components of Cannabis

Most people think of THC and CBD when they think of cannabis. However, cannabis also contains various other components including a range of other cannabinoids and terpenes that also contribute to the entourage effect.

Other common cannabinoids found in cannabis include CBN, CBG, THCV, and CBDV. While research on these cannabinoids is limited compared to research on THC and CBD, they seem to contribute to the beneficial effects of cannabis. For instance, CBN is said to help with sleep as well as having anticonvulsant and anti-inflammatory properties.

Cannabis also contains a range of terpenes. These are essential oils that contribute to the smell and taste of each unique cannabis strain. They can also contribute to the effects of each strain. For instance, limonene is a citrus-scented terpene that’s said to help with anxiety and stress relief. Pinene smells like pine and is said to help with memory and mental focus. Each strain contains a range of terpenes in different concentrations.

How To Use CBD and THC Together

How To Use CBD and THC Together

The best way to experience the entourage effect is to use CBD and THC together. While some cannabis strains contain high levels of both THC and CBD, these are generally quite rare. However, you can use products that give you an even dose of THC and CBD so you can get the best of both worlds.

1:1 CBD/THC Tincture is a great way to use CBD and THC in conjunction. Each dose contains an even serving of CBD and THC. All you have to do is measure your dose with the dropper, apply it under your tongue, and hold it there for a minute or two to absorb the cannabinoids into your system.

You can also use 1:1 CBD/THC Jelly Bombs. Each gummy contains 5mg of CBD and 5mg of THC, but you can always take more than one for stronger effects. These can take 30-90 minutes to kick in, but when they do, you’ll get a sensational high that lasts for many hours.


While CBD and THC can both have fantastic effects in their own right, they work best when used together. While many cannabis strains contain both CBD and THC, the best way to use them together is with 1:1 products such as Edibles, Tinctures, and Capsules. You can find all of these and more online at Syinixcannabiscare.


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